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Alg-1001

ALG-1001 approaches multiple indications by collectively turning off the production, reducing the leakage, and inhibiting the growth of aberrant blood vessels. ALG-1001 binds to multiple integrin-receptor sites on cells, preventing adhesion and promoting development of a PVD. In rabbit studies, the peptide completely liquefied the vitreous in 80 percent of injected eyes within a day and produced total PVDs in 60 percent, the company reported this spring. 2 The first human study found that ALG-1001 caused complete PVD in six of 15 treated patients and Topline results from a prospective, double-masked, placebo-controlled phase-2b clinical study evaluating ALG-1001 (Luminate) in patients with diabetic macular edema. ARVO, May 2017. Bausch Health Investor Contact: Administered as an intravitreal injection, Luminate (previously known as ALG-1001) is a synthetic oligopeptide that inhibits 4 integrin receptor sites involved in angiogenesis and vitreolysis. The targeted receptors have functions both upstream and downstream of the VEGF pathways and can be manipulated to prevent new vascular sprouts, inhibit existing neovascularization and reduce fluid. Allegro began a double-blind, placebo-controlled, dose-ranging, international Phase II trial to Read the full 116 word article CHICAGO, IL, USA I October 16, 2014 I Allegro Ophthalmics, LLC, dedicated to establishing Integrin Peptide Therapy as the next-generation pharmaceutical category for the treatment of vitreo-retinal diseases, today announced that it is enrolling patients in a Phase 2 trial that will evaluate the safety and efficacy of Luminate®, previously known as ALG-1001, in patients with diabetic macular Top-line data from a Phase IIb study of a novel integrin peptide (ALG-1001) to treat diabetic macular edema (DME) has indicated encouraging visual acuity gains, including a reduction in central macular thickness (CMT) comparable to that observed with anti-VEGF therapy.
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PLAT OF LOTS 3 TO 8 L66 P53 PLATS, W C R 21/1001 34 X 126 S ALGER W 15 FT LOT 31 ALSO LOT 30 AND E 2 FT LOT 29 PETRYS 

Vol. 12 (2018), No. 5, 1001–1025. DOI: 10.2140/ant.2018.12.1001 Keywords.


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tå":319,"ug":977,"uh":149," tä":1001,"ur":4133,"us":3732,"ut":5916,"um":1694 ":433,"als":266,"alp":43,"alo":92,"aln":53,"alm":341,"all":5251,"alk":219,"alg":32 

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To evaluate the safety and efficacy of Luminate® (ALG-1001) as compared to Avastin® in patients with diabetic macular edema - Stage 1: 120 eligible subjects with DME will be enrolled and randomized to one of 4 treatment groups at an allocation ratio of 1:1:1:1, i.e., one of three doses (1.0 mg, 2.0 mg and 3.0 mg) of Luminate intravitreal injection or Avastin intravitreal injection. A Safety And Efficacy Study Of Alg-1001 In Human Subjects With Symptomatic Focal Vitreomacular Adhesion The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. For the biopharma industry investment, business development and competitive intelligence professionals who require information to support financing, partnering and licensing activities, BCIQ provides accurate information and context to support profitable and strategic decision making.

DOI: 10.2140/ant.2018.12.1001 Keywords.